Migraine headaches can very easily cause a person to lose daily function and enjoyment of life. Preventing and treating migraine headaches, however, is certainly possible with the right combination of medicine and therapy. The exact causes of migraine headaches remain unknown to the medical community, but it is widely held that serotonin levels in the brain play a significant role in the formation of migraine headaches. Low serotonin levels are usually accompanied by a migraine headache.